Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine
نویسندگان
چکیده
منابع مشابه
Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine.
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
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The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA(PT)), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2010
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c0ob00413h